Psoriasis aumenta el riesgo de cancer en general, y entre más severa, más riesgo.

The Risk of Cancer in Patients with Psoriasis 

JAMA Dermatol; 2016 Mar; Fuxench, Shin, et al

MARCH 23, 2016

The link between psoriasis and cancer was small but present in a population cohort study involving more than 1.1 million individuals. The correlation was primarily due to nonmelanoma skin cancer, lymphoma, and lung cancer. 

Participants had no history of HIV, cancer, organ transplants, albinism, or xeroderma pigmentosum at baseline. They had either moderate-to-severe (n=12,290) or mild (n=198,366) psoriasis, or served as controls (n=937,716). 

Among the results:

• Patients with moderate-to-severe psoriasis were 89% more likely to develop lymphoma, compared with 31% for those with mild disease and 34% for controls. 

• Those with moderate-to-severe psoriasis were 61% more likely to develop NMSC, compared with 9% for mild disease and 12% for controls. 

• Those with moderate-to-severe psoriasis were 62% more likely to develop lung cancer, compared with 12% for those with mild disease and 15% for controls.  

• In all 3 groups the risk for any cancer excluding NMSC was roughly the same. 

• No links were observed in breast, colon, or prostate cancer, or leukemia.

Citation: Fuxench Z, Shin D, Beatty A, Gelfand J. The risk of cancer in patients with psoriasis: A population-based cohort

 study in the Health Improvement Network. JAMA Dermatol. 2016;152(3)282-290. doi:10.1001/jamadermatol.2015.4847.