Uso de altos Factores de Protección Solar demostró beneficios en la reducción de melanoma.

Uso de altos Factores de Protección Solar demostró beneficios en la reducción de melanoma en Mujeres en un estudio Noruego.

• © 2016 by American Society of Clinical Oncology

Sunscreen Use and Subsequent Melanoma Risk: A Population-Based Cohort Study

1. Reza Ghiasvand⇑, 
2. Elisabete Weiderpass, 
3. Adele C. Green, 
4. Eiliv Lund and 
5. Marit B. Veierød

+Author Affiliations

1. Reza Ghiasvand and Marit B. Veierød, Institute of Basic Medical Sciences, University of Oslo; Elisabete Weiderpass, Cancer Registry of Norway, Oslo; Elisabete Weiderpass and Eiliv Lund, University of Tromsø–The Arctic University of Norway, Tromsø, Norway; Elisabete Weiderpass, Karolinska Institutet, Stockholm, Sweden; Elisabete Weiderpass, Folkhälsan Research Center, Helsinki, Finland; Adele C. Green, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; and Adele C. Green, University of Manchester, Manchester, United Kingdom.

1. Corresponding author: Reza Ghiasvand, Oslo Centre for Biostatistics and Epidemiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1122 Blindern, N-0317 Oslo, Norway; e-mail: reza.ghiasvand@medisin.uio.no.

Abstract

Purpose To assess melanoma risk in relation to sunscreen use and to compare high– with low–sun protection factor (SPF) sunscreens in relation to sunbathing habits in a large cohort study.

Materials and Methods We used data from the Norwegian Women and Cancer Study, a prospective population-based study of 143,844 women age 40 to 75 years at inclusion with 1,532,247 person-years of follow-up and 722 cases of melanoma. Multivariable Cox proportional hazards regression was used to estimate the association between sunscreen use (never, SPF < 15, SPF ≥ 15) and melanoma risk by calculating hazard ratios and 95% CIs. The population attributable fraction associated with sunscreen use was estimated.

Results Sunscreen users reported significantly more sunburns and sunbathing vacations and were more likely to use indoor tanning devices. SPF ≥ 15 sunscreen use was associated with significantly decreased melanoma risk compared with SPF < 15 use (hazard ratio, 0.67; 95% CI, 0.53 to 0.83). The estimated decrease in melanoma (population attributable fraction) with general use of SPF ≥ 15 sunscreens by women age 40 to 75 years was 18% (95% CI, 4% to 30%).

Conclusion Use of SPF ≥ 15 rather than SPF < 15 sunscreens reduces melanoma risk. Moreover, use of SPF ≥ 15 sunscreen by all women age 40 to 75 years could potentially reduce their melanoma incidence by 18%.

Footnotes

• Supported by the Norwegian Extra Foundation for Health and Rehabilitation through Extra funds and the Norwegian Cancer Society (project number 2011/2/0228). The funding sources had no involvement in the design and conduct of the study; the collection, management, analysis, or interpretation of the data; the preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.

• Authors' disclosures of potential conflicts of interest are found in the article online at www.jco.org. Author contributions are found at the end of this article.