Factores de riesgo para hemangioma infantil.

Dermatology

Written by

 

 

Sarah L Chamlin MD

Gestational Diabetes: A Newly Identified Association With Infantile Hemangiomas 

These investigators systematically evaluated the maternal prenatal risk factors associated with infantile hemangiomas in a large case–control study. Their study confirmed what others have previously reported, including the association of infantile hemangiomas with early gestational age, multiple gestations, maternal progesterone use, gestational hypertension, and preeclampsia. Of note, they reported a new potential association with gestational diabetes mellitus.  

This study strengthens the argument for the theory that infantile hemangiomas are stimulated by exposure to a hypoxic in utero environment. Such an environment is present when preeclampsia, gestational hypertension, or gestational diabetes occur, and this milieu promotes growth factors that stimulate hemangioma growth, including vascular endothelial growth factor A (VEGF-A). Further support for the hypoxia theory is suggested by the increase in glucose transporter 1 (GLUT-1) expression in both infantile hemangiomas and in the placentas of mothers with diabetes. More investigation into this new association is warranted and may shed further light on the cause of this very common birthmark.   

This final infantile hemangioma article reviewed for 2016 further highlights the "2016 Top Stories in Dermatology: Infantile Hemangioma: We Have Come a Long Way."

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

4000-1054

2208-8206

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