Algunos probioticos No son utiles en prevenir Atopia...

Probiotics Fail to Protect Against Eczema or Asthma

The hygiene hypothesis suggests that exposure to bacteria at critical times in the immune system's development may have beneficial effects by reducing the risk for developing allergic diseases. Researchers randomized 184 high-risk infants ≤4 days old to receive either a capsule containing 10 billion colony-forming units of Lactobacillus rhamnosusGG (LGG) probiotic or a control capsule daily for the first 6 months of life. The infants were followed for 5 years.

The primary outcome was the incidence of eczema within 2 years of birth; the secondary outcome was the incidence of asthma and allergic rhinitis within 5 years of birth. All mothers were encouraged to breast-feed; 51% and 45% of the infants in the intervention and control arms, respectively, breast-fed for at least 12 months. The numbers of children born by cesarean delivery were too low for analysis.

At the 2-year mark, the cumulative incidence of eczema did not differ significantly in the control and intervention groups (31% and 29%). At 5 years, the cumulative incidence of asthma also did not differ significantly between groups (17% and 10%).

Editor Disclosures at Time of Publication

• Disclosures for Louis M. Bell, MD at time of publication Grant / Research support NIH Institutional Clinical and Translational Science Award; Agency for Healthcare Research and Quality National Center for Pediatric Practice Based Research Learning; Patient-Centered Outcomes Research Institute Editorial boards Current Problems in Pediatric Adolescent Healthcare

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

4000-1054

2208-8206

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