Antiacidos y antibioticosantes de los 6 meses mayor riesgo de alergias...

Use of Acid-Suppressive Drugs, Antibiotics in Infancy Linked to Increased Allergy Risk

By Kelly Young

Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD

Use of acid-suppressive medications and antibiotics early in infancy is associated with elevated risk for developing allergic diseases in childhood, an observational study in JAMA Pediatrics finds.

Using a military healthcare database, researchers identified 790,000 children free of allergic conditions at age 6 months. Children who received prescriptions for histamine-2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) in the first 6 months of life were at greater risk for all allergic diseases studied except seafood allergy during a median 4.6 years' follow-up. The increased risk was highest for food allergies (adjusted hazard ratios, 2.18 for H2RAs and 2.59 for PPIs), and the relationship was dose-dependent.

Antibiotics were also tied to increased risk for most allergies, with asthma risk being most elevated (adjusted HR, 2.09).

The authors write: "This study provides further impetus that antibiotics and acid-suppressive medications should be used during infancy only in situations of clear clinical benefit."

JAMA Pediatrics article (Free)

Background: NEJM Journal Watch Pediatric and Adolescent Medicinecoverage of common use of acid-suppressive drugs in the NICU (Your NEJM Journal Watch registration required)

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

4000-1054

2208-8206

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