Cuidado con alopurinol en ciertas poblaciones.

Some Racial Groups May Be At Higher Risk Of Potentially Lethal Severe Cutaneous Adverse Reactions To Allopurinol, Researchers Say.

MedPage Today (4/17, Walsh) reports researchers found that "compared with whites and Hispanics, blacks and Asians had triple the risk of allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis." The researchers also found that "among Native Hawaiian/Pacific Islanders, the likelihood of these severe hypersensitivity reactions was even higher." The findings were published online in the Annals of the Rheumatic Diseases.

        Medscape (4/17, Kelly, Subscription Publication) reports the study's "findings support current recommendations that allopurinol be initiated at a dose of 100 mg/day or lower." The study authors "also recommend screening of Asian, black, and native Hawaiian/Pacific Islander patients for the presence of HLA-B*5801 [allele] before initiating allopurinol, particularly those who also have additional risk factors (female, age >60 years, or chronic kidney disease [CKD])."

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

4000-1054

2208-8206

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