HHV 6 y 7 le guiñe al Alzheimer...

Work Hints that Herpesviruses May Have a Role in Alzheimer's

By Joe Elia

Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS

Preliminary work suggests that human herpesviruses 6A and 7 have key roles in Alzheimer disease. The study appears in Neuron.

Investigators mapped networks of protein metabolism and indicators of viral activity, first in a group of people who died with evidence of neuropathology (but not cognitive impairment), and compared them with normal controls. Based on those findings, they mapped three separate cohorts of Alzheimer's patients and controls.

The amount of virus present in certain brain regions correlated with virus-related changes in the metabolism of beta-amyloid precursor protein, a feature of the disease.

The researchers emphasize that their findings "are not sufficient to definitively demonstrate" the connection between the viruses and the disease.

Neuron article (Free)

Background: NEJM Journal Watch Neurology coverage of past infections and cognitive impairment (Your NEJM Journal Watch registration required

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

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