Cremas topicas para el dolor iguales a placebo...

Compounded Pain Creams No Better Than Placebo

By Amy Orciari Herman

Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD

Compounded topical creams are no better than placebo creams for treating chronic pain, according to a study in the Annals of Internal Medicine.

Roughly 400 adults with localized chronic pain (neuropathic, nociceptive, or mixed) were randomized to use a compounded cream (containing, for example, ketamine, gabapentin, lidocaine, and clonidine) or a placebo cream three times daily. At 1 month, participants in both the active-treatment and placebo groups had improved pain scores, but there were no significant differences between the groups, regardless of the type of pain. At 3 months, there still were no significant differences between active treatment and placebo.

The researchers conclude that given the lack of benefit — and high cost — of these creams, their routine use should be discouraged.

Annals of Internal Medicine article (Free abstract)

Background: NEJM Journal Watch Psychiatry coverage of alternatives to opioids for chronic pain (Your NEJM Journal Watch subscription required)

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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