Bakuchiol vs retinol

Published in Dermatology
Journal Scan / Research · February 28, 2019

Topical Bakuchiol vs Retinol for Facial Photoaging

The British Journal of Dermatology

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This study with 44 patients compared the effects of bakuchiol 0.5% cream
applied twice daily versus retinol 0.5% cream applied once daily for
cutaneous facial aging. Both products significantly improved fine wrinkles
and hyperpigmentation with no significant difference between the two treatments. However, retinol was associated with significantly more scaling and stinging than bakuchiol.
In addition to targeting similar pathways as retinoids, bakuchiol inhibits melanin synthesis and has antifungal properties. This plant-derived active ingredient may appeal to patients who prefer "natural" skin care products.
– Caitlyn T. Reed, MD

Abstract

(https://dx.doi.org/10.1111/bjd.16918)

BACKGROUND

Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side-effects.
OBJECTIVES
To compare the clinical efficacy and side-effect profiles of bakuchiol and retinol in improving common signs of cutaneous facial ageing.
METHODS
This was a randomized, double-blind, 12-week study in which 44 patients were asked to apply either bakuchiol 0·5% cream twice daily or retinol 0·5% cream daily. A facial photograph and analytical system was used to obtain and analyse high-resolution photographs of patients at 0, 4, 8 and 12 weeks. Patients also completed tolerability assessment questions to review side-effects. During study visits, a board-certified dermatologist, blinded to study group assignments, graded pigmentation and redness.
RESULTS
Bakuchiol and retinol both significantly decreased wrinkle surface area and hyperpigmentation, with no statistical difference between the compounds. The retinol users reported more facial skin scaling and stinging.
CONCLUSIONS
Our study demonstrates that bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Bakuchiol is promising as a more tolerable alternative to retinol.

Copyright © 2019 Elsevier Inc. All rights reserved.

Article Citation

The British Journal of Dermatology
Prospective, Randomized, Double-Blind Assessment of Topical Bakuchiol and Retinol for Facial Photoageing
Br J Dermatol 2019 Feb 01;180(2)289-296, S Dhaliwal, I Rybak, SR Ellis, M Notay, M Trivedi, W Burney, AR Vaughn, M Nguyen, P Reiter, S Bosanac, H Yan, N Foolad, RK Sivamani
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. (http://www.ncbi.nlm.nih.gov/pubmed/29947134)


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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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