Co2 vs inyección de grasa autologa de células madre para cicatrices post acne...

Published in Dermatology

Journal Scan / Research · August 04, 2019

Evaluation of Autologous Adipose-Derived Stem Cells Vs. Fractional Carbon Dioxide Laser in the Treatment of Post Acne Scars

International Journal of Dermatology

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TAKE-HOME MESSAGE

• This small study included 10 adults with acne scars on the face who underwent a single injection of autologous adipose tissue-derived adult stem cells (AT-ASCs) to scars on one side of the face and three sessions of fractional carbon dioxide laser (FxCR) on the other side of the face. At follow up 3 months post treatment, both sides of the face had significant improvement of acne scarring, however, there was no significant difference between the treatment modalities.

• Findings of the study demonstrated that a single injection of adipose tissue derived adult stem cells into scars is as effective as three treatment sessions of fractional carbon dioxide laser for atrophic acne scarring.

– Caroline K. Crabtree, MD

Abstract

BACKGROUND

Scarring is a distressing outcome of acne, as it causes cosmetic and psychological problems to the patients. Unfortunately no single treatment is satisfactory; instead, employing multiple modalities may have better outcome. Autologous adipose tissue-derived adult stem cells (AT-ASCs) and their secretory factors can stimulate collagen synthesis; angiogenesis and migration of fibroblasts thus regenerate damaged tissues. Also, conventional treatments for acne scarring, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. The aim of the study was to verify the effectiveness of AT-ASCs for the treatment of acne scarring vs. the fractional carbon dioxide laser (FxCR).

SUBJECTS AND METHODS

Split face comparative study included 10 adult patients with post-acne scars on both sides of the face. One side received AT-ASCs single injection while the other received three sessions of FxCR. Scars were then assessed using the global scoring system Goodman and Baron, scar area percent using NIH ImageJ software and functional assessment by measuring the transepidermal water loss (TEWL) and skin hydration. Both sides were followed for three months.

RESULTS

A significant improvement in the degree of scar severity, scar area percent, skin hydration, and TEWL after 3 months of treatment on both sides of the face with insignificant differences between both treatment modalities, provided that AT-ASCs treatment was employed once vs. three sessions of FxCR.

CONCLUSION

One injection of AT-ASCs is as effective as three sessions of FxCR in the treatment of atrophic acne scars.

International Journal of Dermatology

Evaluation of Autologous Adipose-Derived Stem Cells Vs. Fractional Carbon Dioxide Laser in the Treatment of Post Acne Scars: A Split-Face Study

Int. J. Dermatol 2019 Jul 11;[EPub Ahead of Print], RS Abou Eitta, AA Ismail, RA Abdelmaksoud, NA Ghezlan, RA Mehanna

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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