Dupi en otras cosas

Published in Dermatology

Journal Scan / Review · October 26, 2019

Dupilumab Beyond Atopic Dermatitis

Journal of Drugs in Dermatology

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• In this review, the authors found reports of successful treatment of contact dermatitis, hand dermatitis, and chronic spontaneous urticaria (patients also with history of atopic dermatitis) in the published literature. Improvement in alopecia was coincidentally noted in four case reports of patients with AD treated with dupilumab. Eosinophilic annular erythema, anogenital pruritus, and bullous pemphigoid also were reported to improve in isolated case reports.

• While randomized controlled trials supporting efficacy for dupilumab beyond atopic dermatitis within the field of dermatology are lacking, review of the published literature reveals that it may have potential use in several other dermatologic conditions.

– Caroline Crabtree, MD

Abstract

Dupilumab inhibits the interleukin-4 receptor subunit α and is FDA approved for treatment of moderate-to-severe atopic dermatitis. It is a relatively new drug, and whether it is efficacious for other diseases in dermatology is an area of increasing interest. We searched the literature and ClinicalTrials.gov database for uses of dupilumab beyond atopic dermatitis in dermatology and for ongoing studies on new uses for dupilumab. Off-label reports identified described use of dupilumab for several different dermatologic conditions, including allergic contact dermatitis, hand dermatitis, chronic spontaneous urticaria, prurigo nodularis, and alopecia areata. Overall, there is limited but promising data for dupilumab use beyond atopic dermatitis in dermatology. The relatively safe adverse effect profile of dupilumab may make it an option for certain recalcitrant diseases in dermatology, but further studies will be needed to assess its efficacy and determine its best possible use.

Journal of Drugs in Dermatology

Dupilumab in Dermatology: Potential for Uses Beyond Atopic Dermatitis

J Drugs Dermatol 2019 Oct 01;18(10)1053-1055, NJ Maloney, K Tegtmeyer, J Zhao, S Worswick 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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