Isotretinoina vas Acitretina en reacciones acneiformes por EGFRs

Isotretinoin vs Acitretin for EGFR Inhibitor and Small Molecule Tyrosine Kinase Inhibitor Acneiform Eruptions

Journal of the American Academy of Dermatology

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• In this case series, 6 patients on epidermal growth factor receptor (EGFR) inhibitor or tyrosine kinase inhibitors who then developed acneiform eruptions were treated with either isotretinoin or acitretin. Overall, 20% and 80% of isotretinoin patients had moderate or significant improvement, respectively. Both patients treated with acitretin had minimal improvement. There were no side effects associated with retinoid use in these patients.

• Treatment with both isotretinoin and acitretin led to improvement of EGFR or tyroskine kinase inhibitor-induced acneiform eruptions. Isotretinoin may lead to greater clinical improvement, although further prospective studies in larger cohorts are warranted.

– Margaret Hammond, MD

Abstract

We read with great interest Andrews et al's publication on the therapeutic benefits of oral retinoids on acneiform eruptions secondary to epidermal growth factor receptor (EGFR) inhibitors and mitogen-activated protein kinase inhibitors, and wanted to reinforce the findings.

Journal of the American Academy of Dermatology

Choosing Between Isotretinoin and Acitretin for Epidermal Growth Factor Receptor Inhibitor and Small Molecule Tyrosine Kinase Inhibitor Acneiform Eruptions

J Am Acad Dermatol 2020 Oct 08;[EPub Ahead of Print], CM Costello, HE Hill, CM Brumfiel, YW Yang, DL Swanson

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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