Urea al 5 % en un alcohol en gel reduce riesgo de dermatitis de contacto

Ethanol-Based Disinfectants Containing Urea May Reduce Soap Sensitivity

Dermatitis

TAKE-HOME MESSAGE

• In this split-arm study, 20 participants applied ethanol-containing disinfectants with 5% urea twice daily for 17 days on one forearm only, with the contralateral arm serving as a control. The skin treated with 5% urea had less transepidermal water loss, less dryness, and reduced sensitivity to an irritant soap containing sodium lauryl sulfate compared with the untreated control skin.

• Although ethanol-containing hand disinfectants may further disrupt skin barrier function and promote eczema, this study shows that the addition of 5% urea may help improve barrier function. Further investigation is needed to identify protective ingredients to guide proper hand disinfection while reducing the risk of hand dermatitis.

– InYoung Kim, MD, PhD

Abstract

BACKGROUND

The use of disinfectants is crucial to preventing the spread of nosocomial infections in health care workers. As many as 25 applications of hand disinfectants is a realistic default value during a working day. However, alcohol-based hand disinfectants may weaken skin barrier function and induce dryness and eczema, which decrease their acceptance.

OBJECTIVE

To evaluate the effect of ethanol-containing disinfectants with 5% urea on skin barrier function and on sensitivity to an irritant soap (sodium lauryl sulfate [SLS]).

METHODS

Twenty healthy volunteers treated one of their forearms twice daily for 17 days with an ethanol-containing gel with 5% urea. Two types of gels with urea were tested. Treatment was randomized to left or right forearm, and the contralateral forearm served as untreated control. Transepidermal water loss, skin capacitance (dryness), and sensitivity to SLS were evaluated.

RESULTS

Twice-daily application of the urea-containing ethanol gels lowered transepidermal water loss, prevented dryness, and reduced sensitivity to SLS compared with the untreated control skin.

CONCLUSIONS

Improved barrier function using this ethanol gel with urea may have relevance in daily disinfectant procedures.

Dermatitis

Ethanol-Based Disinfectants Containing Urea May Reduce Soap Sensitivity

Dermatitis 2020 Sep 01;31(5)328-332, M Lodén 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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