Articulo sobre micorinjuria y regeneracion del cabello y pigmento. Gracias!

Stem Cells and Development VOL. 0, NO. ja | normal

Micro-injury Induces Hair Regeneration and Vitiligo Repigmentation Through Wnt/β-catenin Pathway

Xiaofeng Han

,

Li Chang

,

Zhijin Qiu

,

Mao Lin

,

Yuyi Wang

,

Deming Liu

,

Qingchun Diao

,

Julia Li Zhong

, and

Prof. David Wei Xu

Published Online: 19 Jan 2022 https://doi.org/10.1089/scd.2021.0276

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Abstract

Extrinsic injury can evoke intrinsic stimulation and subsequently initiate the physiological repair process. This study aims to investigate whether clinically acceptable micro-injury could be employed to create local stimuli to induce hair regeneration and vitiligo repigmentation. A novel device was designed and manufactured to precisely control the micro-injury parameters. Then the most appropriate extent of micro-injury without over-damaging the skin was evaluated. Finally, the effects of micro-injury on hair regeneration and vitiligo repigmentation were examined by macroscopical observation, histological staining, gene and protein expression analysis. We discover that proper micro-injury effectively induces hair regeneration by activating the hair follicle stem cell proliferation and migration downwards to the hair matrix, finally shifting the hair follicle stage from telogen into anagen. On vitiligo model mice, micro-injury also induces the hair follicle melanocyte stem cells to migrate upwards to the interfollicular epidermis, activating and giving rise to melanocytes to repopulate the vitiligo lesion. Mechanistic analysis indicates that the canonical Wnt/-catenin pathway plays a key role in the micro-injury-induced repair process. The present study demonstrates that micro-injury has great potential in inducing hair regeneration and vitiligo repigmentation, laid a foundation to develop a micro-injury-based treatment method in alopecia and vitiligo.