Paninflammation Value in HS

The pan-immune-inflammation value (PIV) is a recently proposed scoring system that includes all immune-inflammatory cells in the peripheral blood count (neutrophil count × platelet count × monocyte count)/lymphocyte count).

Blood Collection-Based Systemic Inflammation Biomarkers for Patients With Hidradenitis Suppurativa

Journal of the European Academy of Dermatology and Venereology: JEADV

TAKE-HOME MESSAGE

• This retrospective study investigates the laboratory data of 142 patients with hidradenitis suppurativa (HS) to identify biomarkers associated with HS severity. Biomarkers were derived from the complete blood count and included the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and the pan-immune-inflammation value (PIV). Of the studied biomarkers, the most promising results were seen with the PIV, which was able to detect Hurley stage III disease with a specificity of 96.5%.

• The pan-immune-inflammation value can serve as a useful biomarker for the identification of severe systemic inflammation in patients with HS.

–  Joshua R. Ortego, MD

Abstract 

BACKGROUND

Hidradenitis suppurativa (HS) is a relatively common chronic inflammatory condition of intertriginous skin. In recent years, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and platelet/neutrophil ratio (PLR) have been shown to be indicators of systemic inflammation correlating with severity of inflammatory conditions.

OBJECTIVES

We aimed to analyse for the first time systemic inflammation biomarkers also including the pan-immune-inflammation value (PIV) and the systemic immune-inflammation index (SII) in HS patients and controls.

METHODS

This study retrospectively investigated clinical and laboratory data of 142 patients with HS. Moreover, a sex-age-matched healthy control group was included. The severity of HS was routinely assessed by the Hurley staging, the mHSS, and the SAHS score. All inflammation-based biomarkers were calculated from absolute values of complete blood counts. Receiver operating characteristics analyses, including Youden index, were performed in order to determine optimal cut-off values and test performance.

RESULTS

Whereas PIV and SII were significantly higher in HS patients, PLR, MLR, and PNR were significantly lower in HS patients when compared to controls. Almost all inflammation-based biomarkers significantly correlated with disease severity. However, PIV was the only test that was significantly associated with HS severity as indicated by a Youden index of 0.56 (associated criterion: 756.4; AUC: 0.79, P < 0.0001).

CONCLUSIONS

Although all systemic inflammation-based biomarkers investigated are more or less associated with HS severity, the PIV appears to have the best performance in this regard. It may be employed in adjunction with the clinical scores for treatment decision making or clinical trial assessments.

Journal of the European Academy of Dermatology and Venereology: JEADV

Complete blood collection-based systemic inflammation biomarkers for patients with hidradenitis suppurativa

J Eur Acad Dermatol Venereol 2022 Apr 24;[EPub Ahead of Print], T Gambichler, S Hessam, P Cramer, N Abu Rached, G Bechara 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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