During the session on cutaneous ageing, Doctor Martine Darchy presented studies on the benefits of taking oral collagen and hyaluronic acid. Oral collagen: a meta-analysis of 19 studies, with a total of 1,120 participants aged 20 to 70 and 95% of women aged 20 to 70, showed the positive results of hydrolysed collagen supplements compared with placebo on skin hydration, elasticity and wrinkles. The result was assessed after ingesting hydrolysed collagen for 90 days (De Miranda et al., Int J Dermatol 2021; 60: 1449-1461). Oral hyaluronic acid (HA): 3 Asian studies showing some success on reducing wrinkles. In a randomised, double-blind placebo-controlled trial, 60 Japanese men and women aged 22 to 59 were treated with 120 mg per day of 2 or 300 kDa HA or placebo for 12 weeks. An analysis of skin imprints on the crow's feet wrinkles and a subjective assessment questionnaire (wrinkles, skin radiance and suppleness) showed a significant improvement in wrinkles in the 300 kDa HA group after 8 weeks, and slightly lower with 2 kDa HA compared with placebo. Oe et al., Clin Cosmet Invest Dermatol 2017; 10: 267-273. Two more studies showed the same thing, one with 240 mg of 38 kDa HA per day for 8 weeks in a group of 14 Japanese subjects in the HA group versus placebo (p<0.01) (Watanabe et al., Jpn Pharmacol Ther 2015; 43: 57-64) and the other in 26 Korean subjects receiving 240 mg of 75 kDa HA for 8 weeks versus placebo (p<0.05) (Kim et al., Food Style 2007; 11:42–46). However, the effect of epidermal and dermal HA is much greater and oral HA is no substitute for injections, but could serve as adjunctive and maintenance treatment. Thus, it seems that the use of HA in combination with biotin, vitamin C, copper and zin |
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