Carcinoma Epidermoide, recurrencia local y metástasis nodular, más numero de carcinomas más recurrencia y reisgo de metastasis.

Patients with multiple cutaneous squamous cell carcinomas (CSCCs) warrant frequent follow-up because they have an elevated risk of local recurrence (LR) and nodular metastases (NM), according to a study of 985 patients with dermally invasive primary CSCC. Researchers found:

• 727 patients had 1 CSCC, 239 had 2 to 9 CSCCs, and 19 had ≥10  CSCCs.

• Most patients with ≥10 CSCCs were immunosuppressed.

• Compared to patients with 1 CSCC, patients with > 1 CSCC had a higher risk of:

◊ LR (1.8 hazard ratio (HR) for 2 to 9 CSCCs and 3.8 HR for ≥10 CSCCs).

◊ NM (3.0 HR for 2 to 9 CSCCs and 4.2 HR to ≥10 CSCCs)

• 10-year cumulative incidence of LR and NM was higher in patients with 2 to 9 CSCCs  (LR, 3.0%; NM, 2.3%) and markedly higher in patients with ≥10 CSCCs (LR, 36.8%; NM, 26.3%).

Citation: Levine DE, Karia PS, Schmults CD. Outcomes of patients with multiple cutaneous squamous cell carcinomas: a 10-year single-institution cohort study. [Published online ahead of print July 15, 2015]. JAMA Dermatol. doi: 10.1001/jamadermatol.2015.1702.