Uso de algunos anthistamínicos, antimuscarinicos y antidepresivos triciclicos.

Se realizo un estudio observacional, sin establecer causalidad, pero debemos tenerlo en cuenta que en adultos mayores de 65 años la ingesta de alguna de estos medicamentos, en forma diaria, por mas de 3 años se observó una mayor incidencia de demencia.

"This large US prospective cohort study suggests a link between those taking high levels of anticholinergic medicines for more than three years and developing dementia in adults over 65.

The main statistically significant finding was in a group taking the equivalent of any of the following medications daily for more than three years: 

• xybutynin chloride, 5mg 
• chlorpheniramine maleate, 4mg 
• olanzapine, 2.5mg 
• meclizine hydrochloride, 25mg 
• doxepin hydrochloride, 10mg"

El articulo:

Gray SL, et al. Cumulative Use of Strong Anticholinergics and Incident Dementia. A Prospective Cohort Study. JAMA Internal Medicine. Published 26 January 2015

Este link explica muy bien y a fondo los puntos anconsiderar para evitar alarma y amarillismo:

http://www.nhs.uk/news/2015/01January/Pages/media-dementia-scare-about-common-drugs.aspx

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

4000-1054

2208-8206

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