No recomiendan el uso de ketoconazol oral.

Oral Ketoconazole Shouldn't Be Given for Skin and Nail Fungal Infections

By Kelly Young

Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS

The oral antifungal ketoconazole (Nizoral) should not be used to treat skin and nail fungal infections, the FDA cautioned on Thursday. The drug, which is not approved to treat those conditions, is associated with increased risk for liver damage, adrenal gland abnormalities, and adverse interactions with other drugs.

In 2013, the skin and nail fungus indications were removed from ketoconazole's label, but the FDA has learned that clinicians are still prescribing the drug for such infections. Since the label change, one patient died after taking ketoconazole to treat a nail fungus infection.

The FDA reminds clinicians that oral ketoconazole tablets should only be used for serious fungal infections when no alternatives are available.

FDA MedWatch safety alert (Free)

Background: Physician's First Watch coverage of 2013 ketoconazole label changes (Free)

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

4000-1054

2208-8206

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