Tetraciclina mas colchicina para Hidradenitis superlativa, interesante estudio.

Tetracycline and Colchicine Effective for the Treatment of Hidradenitis Suppurativa

This small prospective trial assesses the combination of minocycline 100 mg daily and colchicine 0.5 mg BID for the treatment of hidradenitis in 20 patients. After 6 months, improvement was observed in both Hurley stage and Dermatology Quality of Life Index (DLQI). Additionally, a physician's global assessment (PGA) scale was used and showed improvement at 3, 6, and 9 months. No disease worsening was documented during the treatment periods. Nausea, dizziness, vertigo, and diarrhea were reported side effects, but did not warrant treatment discontinuation of treatment. Additionally, no skin hyperpigmentation was noted.

BACKGROUND

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of the follicular epithelium.

OBJECTIVES

The objective of the present study was to evaluate the effectiveness of the combination of tetracycline with colchicine in the treatment of HS.

METHODS

Twenty patients (10 women and 10 men) with HS were included in an open, prospective, pilot study. All patients were treated with 100 mg minocycline administered orally once per day in combination with 0.5 mg colchicine administered twice per day for 6 months followed by a maintenance regimen of 0.5 mg colchicine administered orally twice per day for 3 months. Patients were examined at baseline and thereafter every 3 months for a total of 9 months. The efficacy of the treatment was evaluated using a physician's global assessment (PGA) scale, the Hurley scoring system, and the Dermatology Life Quality Index (DLQI).

RESULTS

A significant improvement in clinical manifestation was reflected in scores on the Hurley scoring system and DLQI. According to the PGA, patients achieved substantial improvement or complete remission. Clinically, all patients started to show signs of improvement within the first 3 months of therapy and continued to improve over the next 6 months.

CONCLUSIONS

This study indicates that the combination of the anti-inflammatory actions of colchicine and minocycline is effective in disease control in HS. Colchicine emerged as a safe option for the maintenance of the obtained result.

Int. J. Dermatol 2017 Jan 04;[EPub Ahead of Print], K Armyra, A Kouris, V Markantoni, A Katsambas, G Kontochristopoulos