Edad, cirrosis y metastasis son los mayores factores de riesgo para SJS y TEN.

Stevens-Johnson Syndrome Comorbidities Examined

Dermatol Online J; 2017 Apr; Ezaldein, et al

May 3, 2017

Age (≥70 years), cirrhosis, and metastatic disease were identified as significantly associated with inpatient mortality after diagnosis with Stevens-Johnson Syndrome (SJS), a recent study found. These findings enhance current understanding of the pathology of this rare, but life-threatening, skin disease, as well as help improve clinical management of high-risk patients to reduce inpatient mortality. Researchers conducted a retrospective cohort study of the 2010-2011 Healthcare Costs and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) database. This study included 1,811 patients who encountered inpatient hospital stays with a discharge diagnosis of SJS. They found:

• 3 age ranges of patients in this study showed significantly increased rates of inpatient mortality by odds ratio (OR): 70-79 years (10.91% mortality, OR=4.57), 80-89 years (10.67% mortality, OR=4.48), and ≥90 years (9.30% mortality, OR=4.22).
• 2 comorbid conditions showed significant association with increased inpatient mortality in SJS by odds-ratio: cirrhosis (14.58% mortality, OR=2.79) and metastatic disease (10.62% mortality, OR=1.87).

Citation:

Ezaldein H, Totonchy M, Chow C, Samuel A, Ventura A. The effect of comorbidities on overall mortality in Stevens-Johnson Syndrome: An analysis of the Nationwide Inpatient Sample. Dermatol Online J. 2017;23(4): 2. permalink:escholarship.org/uc/item/9333c5dw.