Enfermedad de Parkinson incrementa el Riesgo de padecer, Melanoma!

Association Between Melanoma and Parkinson Disease

Mayo Clin Proc; 2017 Jul; Dalvin, Damento, et al

July 19, 2017

There appears to be an association between melanoma and Parkinson disease (PD), according to a recent study. Therefore, physicians may consider counseling patients with melanoma about PD risk and implementing cutaneous and ocular melanoma surveillance in patients with PD. The cohort consisted of 2 phases. Phase I: Rochester Epidemiology Project records were used to identify (between January 1, 1976, and December 31, 2013) patients with PD in Olmsted County, MN, with 3 matched controls per case. Phase II: All Rochester Epidemiology Project cases of melanoma were identified (between January 1, 1976, and December 31, 2014), with 1 control per case. Researchers found:

• Phase I: Patients with PD had a 3.8-fold increased likelihood of having preexisting melanoma as compared with controls.
• Phase II: Patients with melanoma had a 4.2-fold increased risk of developing PD.
• Kaplan-Meier analysis revealed an increased 35-year cumulative risk of PD in patients with melanoma (11.8%) compared with controls (2.6%).
• Patients with melanoma without PD had a 10.5-fold increased relative risk of death from metastatic melanoma compared with patients with melanoma with PD.

Citation:

Dalvin LA, Damento GM, Yawn BP, et al. Parkinson disease and melanoma. Confirming and reexamining an association. Mayo Clin Proc. 2017;92(7):1070-1079. doi:10.1016/j.mayocp.2017.03.014.