Interesante: CD4 es determinante en la prevalencia de Carcionoma Epidermoide en Pacientes con HIV.

Persons Infected with HIV at Higher Risk for New SCC

JAMA Dermatol; ePub 2017 Jul 12; Asgari, Ray, et al

July 19, 2017

HIV-infected persons compared with HIV-uninfected persons were at higher risk for subsequent new squamous cell carcinoma (SCC) but not basal cell carcinoma (BCC), with a dose-response relationship between risk and lower CD4 counts and higher viral loads (VLs), a recent study found. This cohort study analyzed 455 HIV-infected and 1,945 HIV-uninfected patients, all of them members of the Kaiser Permanente Northern California health care plan, diagnosed with at least 1 nonmelanoma skin cancer (NMSC) from 1996-2008 to determine risk of subsequent NMSCs in relation to CD4 count and VL. Researchers found:

• Compared with HIV-uninfected persons, HIV-infected individuals were slightly younger (mean age, 52.5 vs 55.5 years), more likely men (97% vs 92%), more likely to have smoked (57% vs 45%), and less likely to be overweight/obese (50% vs 61%).
• Compared with uninfected individuals, those with HIV infection with a recent biomarker of more severe immune deficiency (CD4 count <200 cells/mL) had a 44% increased risk of subsequent NMSC overall and a 222% increase risk of SCC in particular, suggesting that subsequent SCC risk is associated with immune dysfunction.

Citation:

Asgari MM, Ray GT, Quesenberry Jr CP, Katz KA, Silberberg MJ. Association of multiple primary skin cancers with human immunodeficiency virus infection, CD4 count, and viral load. [Published online ahead of print July 12, 2017]. JAMA Dermatol. doi:10.1001/jamadermatol.2017.1716.