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Hormonal Contraception Tied to Breast Cancer Risk, But Major Concerns Raised About Study Limitations

By the Editors

Use of hormonal contraception is associated with increased breast cancer risk, an observational study in the New England Journal of Medicine finds.

Researchers followed 1.8 million women aged 15–49 in Denmark for roughly 11 years. Current or recent use of any hormonal contraceptive was associated with elevated risk for incident breast cancer, compared with never use (68 vs. 55 breast cancers per 100,000 person-years). Risk increased with longer exposures. Increased risk was also observed with the levonorgestrel-releasing intrauterine device.

In NEJM Journal Watch Women's Health, Dr. Andrew M. Kaunitz explores some of the study's limitations that he thinks may explain the findings.

NEJM Journal Watch Women's Health summary (Your NEJM Journal Watch subscription required)

NEJM article (Free abstract)

NEJM editorial (Subscription required)