Review of Nail Psoriasis | PracticeUpdate

Published in Dermatology

Journal Scan / Review · April 08, 2019

Review of Nail Psoriasis

Acta Dermato-Venereologica

TAKE-HOME MESSAGE

• This review summarizes the different therapeutic options for nail psoriasis. Treatments such as cyclosporine, TNF-α inhibitors, and IL-17 inhibitors demonstrated comparable overall efficacy and long-term results. The strongest evidence for nail psoriasis exists for secukinumab, with efficacy observed up to week 80 when considering all prospective, double-blind trials. Other therapies with limited or variable efficacy include acitretin, phototherapy, methotrexate, and ustekinumab.

• While systemic therapies are not recommended for the treatment of isolated nail psoriasis, these data can be considered when treating patients with cutaneous psoriasis requiring systemic therapy who may also present with nail psoriasis.

– InYoung Kim, MD, PhD

Abstract 

Nail psoriasis affects 50-79% of patients with skin psoriasis and up to 80% of patients with psoriatic arthritis, and can also represent a negative prognostic factor in individuals with plaque psoriasis. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies alone, and relapse is common. Among different systemic agents, secukinumab, a fully human monoclonal antibody targeting interleukin (IL)-17A, is the only antibody supported by a trial specifically conducted in patients with nail psoriasis (the TRANSFIGURE trial) and has the longest follow-up available to date. In this setting, secukinumab is characterized by the highest efficacy at week 16. This review analysed the different therapeutic options for nail psoriasis, focusing on new treatments that have shown promising results in this field.

Acta Dermato-Venereologica

Nail Psoriasis: An Updated Review and Expert Opinion on Available Treatments, Including Biologics

Acta Derm Venereol 2018 Dec 06;[EPub Ahead of Print], F Bardazzi, M Starace, F Bruni, M Magnano, BM Piraccini, A Alessandrini 
http://www.practiceupdate.com/content/review-of-nail-psoriasis/81811


Sent from my iPhone

Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

Please excuse the shortness of this message, as it has been sent from
a mobile device.