Plasma Levels of TNF-α and Adiponectin Differentiate Psoriatic Arthritis From Psoriasis

Psoriasis (PsO) and psoriatic arthritis (PsA) are inflammatory disorders. Circulating biomarkers of inflammation such as interleukin (IL)‐6, tumour necrosis factor (TNF)‐α, and C‐reactive protein (CRP) have been associated with disease severity and progression of PsO and PsA. Adiponectin and leptin are adipose‐derived cytokines, recognized as key regulators of body weight and metabolism. Whether circulating levels of these inflammatory and metabolic biomarkers may predict the risk of PsA in patients with PsO remains unclear.

The British Journal of Dermatology Plasma Levels of Tumour Necrosis Factor-α and Adiponectin Can Differentiate Patients With Psoriatic Arthritis From Those With Psoriasis Br J Dermatol 2019 Jan 29;[EPub Ahead of Print], CM Johnson, K Fitch, JF Merola, J Han, AA Qureshi, WQ Li

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This study included 180 patients with only psoriasis (PsO) and 143 patients with psoriasis and psoriatic arthritis (PsA). Median plasma levels of TNF‐α were significantly higher in patients with PsA compared with those with PsO (3.27 vs 1.32 pg/mL; P<.001). High levels of TNF-α were associated with increased odds of PsA (aOR, 2.25). However, median total adiponectin was lower among patients with PsA, with a significantly inverse association between high levels of total adiponectin and the likelihood of PsA (aOR, 0.61).