Peeling de Retinol

Published in Dermatology

Journal Scan / Research · October 17, 2019

An Advanced, Physician-Strength Retinol Peel Improves Signs of Aging and Acne Across a Range of Skin Types

Journal of Drugs in Dermatology

TAKE-HOME MESSAGE

• In this study, two to four treatments of a 3% retinol peel formulation were administered to 24 patients at 6-week intervals. Patients had a variety of skin concerns, including sun-damaged skin, acne, and melasma. Patients with skin of color were included. All dermatologist-graded aging parameters (including fine lines, laxity, and pore size, among others) were significantly improved after four peels in the photodamage group. Acne and melasma were improved as well, but groups were too small to draw statistical conclusions.

• A superficial chemical peel with a 3% retinol formulation was well-tolerated and led to an improvement of a variety of skin concerns in a diverse patient population.

– Caroline Crabtree, MD

Abstract

BACKGROUND

Facial chemical peels are highly sought after by patients with photodamage, acne, and melasma. An advanced, physician-strength superficial peel, containing 3% retinol with other firming and volumizing ingredients was developed to exfoliate, improve the appearance of fine lines and wrinkles, and plump and firm skin, while promoting a bright, even complexion.

OBJECTIVE

A clinical study was conducted to evaluate the tolerability, safety, and efficacy of the 3% retinol peel with a supportive homecare regimen across a range of peel candidates, females aged 18-65 years, with photodamage, acne, hyperpigmentation or melasma, and skin of color, over a series of 2-4 peels. Method: The 3% retinol peel formulation was administered under physician direction in 6-week intervals. Subjects with photodamaged skin, acne, hyperpigmentation/melasma, or skin of color (Fitzpatrick skin types IV-VI) received 2-4 peels along with a supportive homecare regimen. Dermatologist grading, self-assessment, and digital photography documented tolerability and efficacy parameters.

RESULTS

24 subjects participated in the study with a total of 78 peels administered (Photodamage group, n=14 [with an Acne subgroup, n=5]; Melasma group, n=5; Skin of Color, n=5). The 3% retinol peel along with the homecare regimen was well tolerated under physician direction in all skin types and conditions assessed. Obvious peeling was noticeable in many subjects 3 days post-peel and resolved by day 7. In the photodamaged group, dermatologist clinical grading of fine lines, wrinkles, pore size, laxity, mottled pigmentation, lack of clarity/radiance, and overall photodamage was significantly improved (P<0.05). Benefits were observed in all groups and supported by self-assessment. Digital photography demonstrated tolerability in the days immediately post-peel, along with benefits to photodamage.

CONCLUSION

The 3% retinol superficial peel was well tolerated and an efficacious cosmetic treatment under physician supervision in subjects of all skin types to firm skin, improve fine lines and wrinkles, and promote a bright, even complexion.

Journal of Drugs in Dermatology

An Advanced, Physician-Strength Retinol Peel Improves Signs of Aging and Acne Across a Range of Skin Types Including Melasma and Skin of Color

J Drugs Dermatol 2019 Sep 01;18(9)918-923, N Sadick, BL Edison, G John, KL Bohnert, B Green 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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