Secuelas de Lupus Neonatal

Published in Dermatology

Journal Scan / Research · November 14, 2019

Cutaneous Sequelae in Neonatal Lupus

Journal of the American Academy of Dermatology

TAKE-HOME MESSAGE

• Of 106 patients with cutaneous neonatal lupus erythematosus (NLE), 34% had cutaneous sequelae at the last documented follow-up at a mean age of 4 years. Residua included telangiectasia (13%), dyspigmentation (17%), and atrophic scarring (9%). Scarring was associated with having skin lesions at birth (P<.001).

• Whereas cutaneous eruptions in NLE are thought to be self-resolving, this retrospective study demonstrates that cutaneous sequelae may persist. Long-term monitoring and appropriate counseling are recommended.

– InYoung Kim, MD

Abstract

BACKGROUND

Cutaneous eruptions in neonatal lupus erythematosus (NLE) are thought to be self-resolving. Limited literature suggests cutaneous changes may persist.

OBJECTIVE

To characterize cutaneous residua in NLE, and identify predictors for their development.

METHODS

A retrospective cohort study of patients with cutaneous NLE born between January 1980 and May 2017 was performed. Primary outcome was the proportion of patients with cutaneous residua. Secondary outcomes included associations/predictors of sequelae.

RESULTS

At last follow up, at a mean age of 4 (range, 0.5-18.7) years, 34% of 106 patients had cutaneous sequelae;13% had telangiectasia, 17% had dyspigmentation, and 9% had atrophic scarring. Scarring at last follow-up was significantly associated with presence of skin lesions at birth (p<0.001).

LIMITATIONS

This study was limited by retrospective design, short follow-up duration in a subset of patients, and small sample size.

CONCLUSIONS

Cutaneous NLE can exhibit long-term cutaneous residua. These findings underlie the importance of accurate diagnosis, long-term monitoring and appropriate counseling.

Journal of the American Academy of Dermatology

Cutaneous Sequelae in Neonatal Lupus: A Retrospective Cohort Study

J Am Acad Dermatol 2019 Oct 15;[EPub Ahead of Print], R Levy, L Briggs, E Silverman, E Pope, I Lara-Corrales

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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