Dxc en ulceras

Published in Dermatology

Journal Scan / Research · December 04, 2019

Contact Sensitization in Patients With Chronic Leg Ulcers

Advances in skin & wound care

TAKE-HOME MESSAGE

• A retrospective chart review was conducted of 145 patients with chronic lower-extremity ulcers who underwent patch testing. All patients were tested to the European Baseline Series S-1000, Leg Ulcer Series LU-1000, and commonly used hydrocolloid or silicone dressing and antiseptic series.

• Contact sensitization was found in 57 patients (64.8%), most commonly to benzalkonium chloride (n = 27), balsam of Peru (n = 26), and povidone-iodine 10% ointment (n = 25). Patients who complained of itch around an ulcer more frequently had a positive patch test than those who had no itching (74.1% vs 55.2%). There was no relationship between duration of ulcer, type of ulcer, presence of exudate, or presence of leg eczema with positive patch tests.

– Caitlyn T. Reed, MD

Abdtract

OBJECTIVES

To determine the frequency of contact sensitization among patients with chronic leg ulcers; to identify the most common allergens; and to examine possible relationships to ulcer duration, itching, exudate, and leg eczema.

METHODS

Researchers conducted a 5-year retrospective analysis of 145 patients diagnosed with chronic leg ulcers who underwent skin patch testing with S-1000, LU-1000, and the commonly used dressing and antiseptic series.

RESULTS

Investigators included 88 females (60.7%) aged 64 ± 15.1 years and 57 males (39.3%) aged 61 ± 16.4 years. Of these, 62.8% (n = 91) of patients were sensitized to at least one substance (2.6 ± 1.4 allergens on average). The most common allergens were benzalkonium chloride (18.6% [n = 27]), balsam of Peru (17.9% [n = 26]), and povidone-iodine 10% (17.2% [n = 25]). Finally, 40% (n = 58) of patients presented with pruritus around the ulcer, which was strongly associated with a positive patch test reaction (74.1% [n = 43] vs 55.2% [n = 48]; P = .021) and polysensitization (3.5 sensitivities [95% confidence interval, 2.4-4.6] vs 2 [95% confidence interval, 1.2-2.8]).

CONCLUSIONS

Contact sensitization is very common in patients with chronic leg ulcers, and pruritus around the ulcer is associated with contact allergy as well as polysensitization.

Advances in skin & wound care

Contact Sensitization in Patients with Chronic Leg Ulcers: Results of a 5-Year Retrospective Analysis

Adv Skin Wound Care 2019 Dec 01;32(12)558-562, T Raudonis, RA Vankeviciute, A Lideikaite, AG Grigaityte, J Grigaitiene 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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