Crisaborole off label

Off-Label Therapeutic Potential of Crisaborole

Journal of cutaneous medicine and surgery

TAKE-HOME MESSAGE

• This review summarizes the current body of literature on use of topical crisaborole, a selective PDE-4 inhibitor, in treating inflammatory dermatologic conditions other than atopic dermatitis. In a small double-blind randomized controlled trial of patients with intertriginous, anogenital, or facial psoriasis, use of crisaborole was associated with 66% improvement in target-lesion severity score compared with 9% in the vehicle arm. Case reports of successful treatment of palmoplantar psoriasis, seborrheic dermatitis, and inflammatory linear verrucous epidermal nevus with crisaborole are also described.

• Although the literature currently consists of only a handful of case reports, series, and small studies, crisaborole 2% ointment may prove effective in a variety of inflammatory dermatologic conditions. Further studies are warranted to substantiate these findings.

– Margaret Hammond, MD

Abstract 

Crisaborole, a topical phosphodiesterase-4 inhibitor, was recently approved in 2016 for the treatment of mild to moderate atopic dermatitis in adults and children greater than 2 years of age. Since that time, several case reports and a small randomized controlled trial have been published regarding the off-label use of crisaborole for the treatment of other inflammatory dermatologic disorders. This paper reviews the current, albeit limited, evidence for off-label use of crisaborole for psoriasis, seborrheic dermatitis, vitiligo, and inflammatory linear verrucous epidermal nevus. Additional potential therapeutic uses for crisaborole are also postulated, based on its mechanism of action. Future studies are required to elucidate the full therapeutic potential of crisaborole; however, it is a welcome addition to the current nonsteroid topical treatments for inflammatory dermatologic disease.

Journal of cutaneous medicine and surgery

Off-Label Therapeutic Potential of Crisaborole

J Cutan Med Surg 2020 Mar 05;[EPub Ahead of Print], C Makins, R Sanghera, PS Grewal 

Sent from my iPhone

Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

Please excuse the shortness of this message, as it has been sent from
a mobile device.