Gel al 1% de MTX para AA

Topical Methotrexate 1% Gel for the Treatment of Localized Alopecia Areata

International Journal of Dermatology

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• The authors report two cases of patients with localized alopecia areata who refused intralesional steroid injection. Instead, the patients were treated with topical methotrexate 1% gel twice daily. Both patients experienced mild burning, scaling, and redness that did not require treatment discontinuation. One patient decreased the use to once daily. After 2 months of treatment, both patients had regrowth of terminal hairs, and treatment was stopped.

• Further studies are needed to determine whether topical methotrexate is an acceptable alternative to intralesional steroid injection for patients with alopecia areata.

– Caitlyn T. Reed, MD

Abstract

Alopecia areata is a commonly encountered clinical problem. Although it is non-cicatricial with chances of self-reversal, it causes significant cosmetic concern. The treatment of choice for localized disease is intralesional steroid injection, which, though usually effective, is an invasive, painful procedure and may require repeated sessions, affecting patient compliance. The treatment of this common condition has remained a thera- peutic challenge and dilemma. We report here the use of topical methotrexate 1% gel as one possible solution to this challenge.

International Journal of Dermatology

Topical Methotrexate 1% Gel for the Treatment of Localized Alopecia Areata

Int. J. Dermatol 2020 Apr 28;[EPub Ahead of Print], G Ahmed, S Khare, S Ganguly, N Chhabra, N Prabha