Zinc y Nicotinamida en HS leve a mod

Efficacy of Oral Zinc and Nicotinamide as Maintenance Therapy for Mild–Moderate Hidradenitis Suppurativa

Journal of the American Academy of Dermatology

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• Patients with mild to moderate hidradenitis suppurativa who had all achieved clinical efficacy with a 12-week course of minocycline were given either a maintenance regimen of combination zinc 90 mg and nicotinamide 30 mg daily for 12 weeks or no treatment. At 12 weeks, severity (4.0 vs 6.2; P = .004), pain (2.0 vs 6.5; P = .003), and DLQI (2.9 vs 7.5; P = .002) scores were all significantly lower among treated patients. These differences were also maintained when patients were off supplements at 24 weeks. The maintenance intervention significantly improved the disease-free interval (20.4 vs 5.4 weeks; P = .001). In the intervention group, 2 patients experienced nausea but did not discontinue treatment.

• Many patients with hidradenitis suppurativa seek out complementary therapies, including zinc and nicotinamide. The findings of this study suggest that a combination of zinc and nicotinamide may be well-tolerated and effective in improving clinical outcomes and disease-free interval in patients who have completed a course of antibiotics with clinical efficacy.

– Margaret Hammond, MD

Abstract

Hidradenitis suppurativa (HS) is a chronic cutaneous disease that involves follicular occlusion in the apocrine gland-bearing regions. Treatment is a challenge because of the paucity of effective therapies and frequent exacerbations, with a negative impact on quality of life.1 Brocard et al first described zinc gluconate (90 mg daily for 4 months) as an effective therapeutic alternative for the management of HS.

Journal of the American Academy of Dermatology

Efficacy of Oral Zinc and Nicotinamide as Maintenance Therapy for Mild–Moderate Hidradenitis Suppurativa

J Am Acad Dermatol 2020 Apr 24;[EPub Ahead of Print], E Molinelli, V Brisigotti, A Campanati, C Sapigni, A Giacchetti, C Cota, A Offidani 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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