BP topical treatment

Superpotent Topical Corticosteroid Therapy in Bullous Pemphigoid

The British Journal of Dermatology

TAKE-HOME MESSAGE

• This prospective observational study of 95 patients with newly diagnosed bullous pemphigoid (BP) was conducted at the Autoimmune Bullous Diseases Reference Centre at the Department of Dermatology of Reims University Hospital. Monotherapy with topical corticosteroids was started in 59 patients (62%), with variable usage of 20 to 30 g of clobetasol cream daily depending on extent of disease.

• Of the 59 patients treated initially with topical corticosteroids alone, 34 (58%) were continued on this therapy successfully up through the 1-year follow-up period, indicating that topical corticosteroid monotherapy was sufficient for 36% of patients with newly diagnosed BP. Those requiring systemic therapy had higher BP disease area index (BPDAI). Further studies are needed to determine the BPDAI cutoff for patients who should be treated with topical corticosteroid monotherapy or started initially on systemic therapy.

– Caroline K. Crabtree, MD

Abstract

Superpotent topical corticosteroids (TCS) have been demonstrated to be more effective and safer than high doses of oral corticosteroids to treat extensive bullous pemphigoid (BP).1 They are proposed as first‐line treatment for BP in the Cochrane review2 and in European guidelines.3 In France, TCS are the recommended first‐line treatment for BP, regardless of disease severity.4 The objectives of this study were to determine whether TCS alone were actually used as first‐line therapy and could be successfully continued during the first year of treatment in routine practice, and to estimate the related healthcare costs.

The British Journal of Dermatology

Feasibility and Healthcare Costs of Superpotent Topical Corticosteroid Therapy in Bullous Pemphigoid: A Prospective, Observational Study in an Academic Centre in France

Br J Dermatol 2020 Apr 22;[EPub Ahead of Print], A Clapé, C Muller, J Plée, M Viguier, C Vanhaecke, P Bernard 

Sent from my iPhone

Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

Please excuse the shortness of this message, as it has been sent from
a mobile device.