Subcorneal Pustular Dermatosis Successfully Treated With Low‐Dose Doxycycline International Journal of Dermatology

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• The authors report the case of a 43-year-old woman diagnosed with subcorneal pustular dermatosis after Mycoplasma pneumoniae infection. The patient refused treatment with dapsone and acitretin and continued to flare after 1 month on oral prednisolone. She was transitioned to doxycycline 40 mg daily and at 10-week follow-up, the patient had only post-inflammatory hyperpigmentation with no residual pustules. Remission was maintained 6 months after stopping therapy.

• Low-dose doxycycline may be a safe and effective treatment option for subcorneal pustular dermatosis. The authors hypothesize that the efficacy may be related to the targeting of the inflammatory cytokines that are pathogenic in subcorneal pustular dermatosis.

–  Caroline K. Crabtree, MD

Abstract 

First described by Sneddon and Wilkinson in 1956, subcorneal pustular dermatosis (SPD) is a rare, chronic, relapsing disease included in the complex group of neutrophilic dermatoses.1, 2Typically affecting middle‐aged women, it is characterized by a symmetrical sterile pustular eruption, which mainly involves the trunk, the intertriginous areas of the body, and the flexor aspects of the limbs. The treatment of choice is dapsone; corticosteroids, retinoids, phototherapy, infliximab, and pentoxyfilline have been used in resistant cases.3 Relapses after treatment discontinuation have been reported, and maintenance therapy should be considered. We report a case of SPD successfully treated with low‐dose doxycycline.

International Journal of Dermatology

Subcorneal Pustular Dermatosis Successfully Treated With Low‐Dose Doxycycline

Int. J. Dermatol 2021 Apr 16;[EPub Ahead of Print], F Borgia, A Campitiello, L Di Bartolomeo, R Cardia, I Marafioti, SP Cannavò

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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