Topical Sirolimus Therapy for Nevus Sebaceus and Epidermal Nevu Journal of the American Academy of Dermatology

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• The authors treated 3 patients with nevus sebaceus (NS) and 2 patients with epidermal nevus (EN) with topical sirolimus 1% cream twice daily. A scalp NS in 1 patient was 90% flatter after 2 months and has remained stable for 5 years after tapering application to once weekly. The other patients noted thinning of their NS and EN after 1 to 4 months of treatment. A single patient discontinued treatment due to flakiness, itchiness, and redness.

• Topical sirolimus 1% cream is a safe and effective option for patients with NS or EN who decline surgical management.

–  Katherine M. Stiff, MD

Nevus sebaceus (NS) and epidermal nevus (EN) are relatively common birthmarks. Treatment can be challenging because these lesions may occur in locations where excision would likely result in disfigurement. Some patients decline surgery but still desire treatment to diminish the visibility of their birthmark.

Journal of the American Academy of Dermatology

Topical sirolimus therapy for nevus sebaceus and epidermal nevus: A case series

J Am Acad Dermatol 2021 Aug 21;[EPub Ahead of Print], AG Zhou, RJ Antaya 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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