Combination Therapy With 308-nm Excimer Lamp and Topical Tacrolimus or Clobetasol 17-Propionate for Localized Vitiligo

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In this retrospective study, 82 vitiligo patients were treated with 308-nm excimer lamp (previously found to have no superior efficacy over excimer laser) as a monotherapy or in combination with either topical tacrolimus or topical clobetasol applied twice daily. Median healing after 24 sessions was higher in the excimer + tacrolimus group (69%) compared with excimer lamp alone (42.5%) and excimer lamp + clobetasol (44%). Excimer + tacrolimus was superior to excimer + clobetasol in multivariate regression analysis.
Repigmentation rates in vitiligo were higher in patients treated with excimer lamp plus topical tacrolimus than in those treated with excimer lamp alone or in combination with clobetasol.