Más crio, para las queratosis actinicas en la Cara!

Published in Dermatology

Journal Scan / Research · March 27, 2017

Actinic Keratosis Cleared With Aggressive Freezing Techniques

Dermatologic Surgery

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TAKE-HOME MESSAGE

• This study examined the cryosurgery spray technique for the treatment of actinic keratoses (AKs) on the head in 329 patients. Overall, less-aggressive freezing techniques were used for AKs on the face as compared with those on the scalp. A shorter duration of 1 to 4 seconds of spray (face) was involved vs 5 to 8 seconds (scalp), and a smaller number of freeze–thaw cycles of one (face) vs two (scalp). No difference in the distance from the tip of the spray device to the lesion was noted for AKs treated on the face and scalp. At 11 weeks, AK clearance on the face was higher with more aggressive freezing techniques.

• AKs on the face are treated less aggressively than AKs on the scalp. Dermatologists may consider customizing the duration of cryosurgery spray and number of freeze–thaw cycles to improve clearance rates of AKs on the face.

  – Jeffrey Scott, MD

BACKGROUND

Cryosurgery is the most commonly used method to treat actinic keratosis (AK). Cryosurgical methods are not standardized.

OBJECTIVE

To examine differences in the spray techniques used for liquid nitrogen cryosurgery when treating AKs of the head, and the effect of these variations in technique on rates of complete clearance of AKs.

MATERIALS AND METHODS

Patients were those from the FIELD-1 study, who received cryosurgery as per the investigators' usual practice to all AKs. This was followed by topical treatment with either vehicle gel or ingenol mebutate gel, 0.015%, after 3 weeks. The investigator recorded the average duration of cryosurgery spray used, the number of freeze-thaw cycles, and the distance from the tip of the spray device to the AK. Clearance rates were determined at Week 11.

RESULTS

Less-aggressive freezing techniques were used for AKs on the face than for those on the scalp. However, higher rates of complete clearance on the face and scalp were associated with more-aggressive freezing techniques.

CONCLUSION

Patients with AKs on the face receive less-aggressive cryosurgery than do patients with AKs on the scalp.

Variables in Cryosurgery Technique Associated With Clearance of Actinic Keratosis

Dermatol Surg 2017 Mar 01;43(3)424-430, B Berman, AQ Shabbir, T MacNeil, KM Knudsen