Ibuprofeno mas acetaminofen son potentes analgesicos!

Ibuprofen + Acetaminophen Seems as Effective as Opioids + Acetaminophen for Acute Extremity Pain

By the Editors

Ibuprofen and opioids are similarly effective for short-term relief of acute extremity pain when combined with acetaminophen, according to a JAMAstudy.

Some 400 adults presenting to the emergency department with moderate-to-severe acute extremity pain (e.g., from sprain or fracture) were randomized to one of four single-dose oral treatments:

• Ibuprofen (400 mg) and acetaminophen (1000 mg)
• Oxycodone (5 mg) and acetaminophen (325 mg)
• Hydrocodone (5 mg) and acetaminophen (300 mg)
• Codeine (30 mg) and acetaminophen (300 mg)

At 2 hours, pain scores had declined in all groups, with no statistically or clinically significant differences across the groups.

Dr. Daniel Pallin of NEJM Journal Watch Emergency Medicine offers his take on the findings at the link below.

Why We Chose This as One of Our Top Stories:

Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, DFASAM:This story gives some concrete evidence for clinicians to feel empowered to use non-opioids for first-line treatment in acute musculoskeletal pain.

NEJM Journal Watch Emergency Medicine summary (Your NEJM Journal Watch subscription required)

JAMA article (Free abstract)

JAMA editorial (Subscription required)

Benjamin Hidalgo-Matlock

Skin Care Physicians of Costa Rica

4000-1054

2208-8206

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