Comentario muy interesante en la discusión de un articulo sobre un mecanismo del HPV en cancer de cervix....

Human papillomavirus E7 induces p63 expression to modulate DNA damage response

• Sahar Eldakhakhny, 
• Qing Zhou, 
• Emma J. Crosbie & 
• Berna S. Sayan

• Cell Death & Diseasevolume 9, Article number: 127(2018)
• doi:10.1038/s41419-017-0149-6
• Download Citation

Received:

05 June 2017

Revised:

13 November 2017

Accepted:

15 November 2017

Published online:

26 January 2018

HPVs infect cells at the basal layer of stratified epithelia, where the p53 family protein p63 is highly expressed and is essential for proliferation49,50. Although in normal stratified epithelia the only pool of mitotically active cells is located in the basal and parabasal layers9, following HPV infection, cells at suprabasal layers keep their proliferative capacity to replicate the HPV genome8,38. This is mostly achieved by HPV E7 protein, which forces cell cycle progression by inducing degradation of pRb17. In moderate and severe cervical dysplasia, where cells at suprabasal layers still undergo proliferation, p63 is expressed throughout the stratified epithelia23,25, suggesting a possible relationship between the expression of E7 and p63.