Apnea y depresión

Obstructive Sleep Apnea Associated with Later Risk for Depression, Anxiety

By Amy Orciari Herman

Edited by André Sofair, MD, MPH

Adults with obstructive sleep apnea (OSA) may face increased risk for affective disorders, according to a prospective study in JAMA Otolaryngology—Head & Neck Surgery.

Using national South Korean health insurance data, researchers matched roughly 200 adults with OSA to 800 without apnea. The study excluded those with histories of depression or anxiety. (Information on OSA treatment compliance was unavailable.)

During 9 years' follow-up, the incidence of affective disorders was 50 per 1000 person-years in the OSA group versus 27 per 1000 in the comparison group. After multivariable adjustment, the OSA group had nearly three times the risk for depressive disorders and nearly twice the risk for anxiety disorders as the comparison group. Risks were higher among females than males.

The researchers cite evidence suggesting that daytime sleepiness is associated with depression, while other evidence implicates "structural or metabolic changes in the brains of patients with OSA."

JAMA Otolaryngology—Head & Neck Surgery article (Free abstract)

Background: NEJM Journal Watch Psychiatry coverage of apnea treatment and improved depression (Your NEJM Journal Watch subscription required)

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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