Acne y Enfermedad Inflamatoria Intestinal

Published in Dermatology

Journal Scan / Research · June 11, 2022

Genetic Liability to Acne Is Associated With Increased Risk of Inflammatory Bowel Disease

Journal of the American Academy of Dermatology

TAKE-HOME MESSAGE

• Recently, there has been speculation that acne is associated with inflammatory bowel disease (IBD), irrespective of isotretinoin use. To investigate this association, the authors used genome-wide significant single-nucleotide polymorphisms from 20,165 acne cases and 595,231 controls of European ancestry and compared the incidence of IBD. The findings indicate that the genetic liability to acne is positively associated with IBD, specifically with ulcerative colitis.

• Acne may be an independent risk factor in the development of ulcerative colitis.

–  Katherine M. Stiff, MD

Abstract

Isotretinoin, an effective mediation prescribed for severe acne, has been suspected to trigger inflammatory bowel disease (IBD). However, with more recent evidence that supports null association between isotretinoin exposure and IBD risk, there is a growing speculation as to whether IBD may in fact be part of the consequences of acne itself, rather than the side-effect of isotretinoin treatment. Only 1 population-based study has previously touched on this hypothesis, indicating a direct effect of acne on IBD. As the causal association is difficult to establish depending solely on classical observational designs, we performed a 2-sample Mendelian randomization (MR) study to test the hypothesis that acne would increase the risk of IBD. MR leverages randomly allocated genetic variants as instruments (Fig 1), which could infer the causal effect of an exposure on an outcome by minimizing confounding and reverse causality.

Journal of the American Academy of Dermatology

Genetic liability to acne is associated with increased risk of inflammatory bowel disease: A Mendelian randomization study

J Am Acad Dermatol 2022 May 02;[EPub Ahead of Print], J Zhu, D Zhou, J Wei, Y Li 

Sent from my iPhone

Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

Please excuse the shortness of this message, as it has been sent from
a mobile device.