DNA Damage and Somatic Mutations in Mammalian Cells After Irradiation With a Nail Polish Dryer Nature Communications

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• In this study, mammalian cell lines with acute or chronic exposure to ultraviolet (UV) nail polish dryers were found to have mutagenic and cytotoxic changes on in vitro clonal expansion models. Specifically, genomic profiling revealed higher levels of mutations in cells exposed to UV nail polish dryer, with C > A mutations being highly elevated compared with controls. These mutagenic changes were previously attributed to reactive oxygen species.
• UV nail polish dryers induce cytotoxic and mutagenic changes on in vitro cell line models and may cause cancers of the hand.

–  Kelly B. Scarberry, MD

Abstract

Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation emitted by UV-nail polish dryers on mammalian cells. Here, we show that irradiation by a UV-nail polish dryer causes high levels of reactive oxygen species, consistent with 8-oxo-7,8-dihydroguanine damage and mitochondrial dysfunction. Analysis of somatic mutations reveals a dose-dependent increase of C:G>A:T substitutions in irradiated samples with mutagenic patterns similar to mutational signatures previously attributed to reactive oxygen species. In summary, this study demonstrates that radiation emitted by UV-nail polish dryers can both damage DNA and permanently engrave mutations on the genomes of primary mouse embryonic fibroblasts, human foreskin fibroblasts, and human epidermal keratinocytes.

Nature Communications

DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer

Nat Commun 2023 Jan 17;14(1)276, M Zhivagui, A Hoda, N Valenzuela, YY Yeh, J Dai, Y He, SP Nandi, B Otlu, B Van Houten, LB Alexandrov 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
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