Cocamidopropyl Betaine en Pediatria

Published in Dermatology

Journal Scan / Research · January 20, 2020

Cocamidopropyl Betaine Is Commonly Found in Hypoallergenic Personal Care Products for Children

Journal of the American Academy of Dermatology

TAKE-HOME MESSAGE

• Of the top 6 online retailers for baby shampoo and baby soap, 52% (39/75) of unique shampoo and 43.9% (29/66) of unique soap products contained cocamidopropyl betaine (CAPB). Among those found in more than one query of the product databases of these retailers, 61.9% (13/21) of shampoo and 78.6% (11/14) of soap products contained CAPB. The term "hypoallergenic" was present on either the label of the product itself or in the product's description.

• Based on previous studies demonstrating a strong association of CAPB contact sensitivity with atopic dermatitis (AD), CAPB is thought to be a prevalent sensitizer that should be avoided in AD patients. Unfortunately, CABP was frequently found in pediatric shampoo and soap products that were marketed as "hypoallergenic." Given that CAPB is prevalent in pediatric products but not included on the TRUE test, the authors recommend expanded or custom patch testing to include CAPB when contact sensitivity is suspected in children with AD.

– InYoung Kim, MD, PhD

Atopic dermatitis (AD), found in approximately 15% of pediatric patients in the United States, is an inflammatory skin condition associated with poor skin barrier function, resulting in significantly higher rates of cutaneous delayed-type hypersensitivity and allergic contact dermatitis (ACD) compared to nonatopic populations1 particularly to weaker allergens.2 In 2014, Shaughnessy et al. analyzed 1674 patients with and without AD who underwent patch testing with the North American Contact Dermatitis Group patch series for reactivity to surfactants, products known to worsen skin barrier dysfunction and aggravate skin inflammation in patients with ACD and AD.1 Their study determined an association between cocamidopropyl betaine (CAPB) contact sensitivity and a history of AD, and concluded that children with AD should not be exposed to CAPB;1 these results are supported by our recent study of a pediatric cohort wherein all CAPB reactions came exclusively from patients with AD.3 Despite being the allergen with the 8th 18 most frequent reactions in a recent 10-year retrospective chart review of pediatric patients, CAPB is commonly found in products branded as "hypoallergenic" which are recommended for children with ACD or AD.4 This study aims to assess the frequency of CAPB inclusion in commonly purchased pediatric hypoallergenic personal care products.

Journal of the American Academy of Dermatology

Cocamidopropyl Betaine Is Commonly Found in Hypoallergenic Personal Care Products for Children

J Am Acad Dermatol 2019 Dec 21;[EPub Ahead of Print], RW Collis, DM Sheinbein 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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