Diferentes: DA Adultos vs Niños

Published in Dermatology

Journal Scan / Research · May 27, 2020

Clinical and Laboratory Differences Between Early-Onset and Late-Onset Adult Atopic Dermatitis

Journal of cutaneous medicine and surgery

TAKE-HOME MESSAGE

• The authors retrospectively reviewed 214 adult patients with atopic dermatitis who were divided into two groups based on age of onset. Of the total, 151 (70.6%) belonged to the early-onset group, with onset at age < 12 years, compared with 29.4% in the late-onset group. In the late-onset group, most patients were 25 to 40 years (63.4%) at time of initial visit, and only 3 patients (4.7%) were older than 40 years. Compared with the early-onset group, the late-onset group had fewer first-degree relatives with atopic dermatitis (15.8% vs 29.8%), a lower total serum IgE, and a lower incidence of allergic asthma or rhinitis. The late-onset group had a higher likelihood of non-flexural involvement (38.1% vs 13.2%, P < .001).

• The results of this study suggest that there are differences in the clinical features of atopic dermatitis patients based on age of onset. Larger studies are needed to further delineate the various phenotypes of adult atopic dermatitis.

– Margaret Hammond, MD

Abstract 

BACKGROUND

Atopic dermatitis (AD) in adults is not uncommon, and its prevalence has been increasing in the recent decades. However, there is a paucity of data about the differences between early-onset and late-onset adult AD.

OBJECTIVE

The objective of this study is to investigate the clinical and laboratory characteristics of adult AD, focusing on the differences between early-onset and late-onset adult AD.

METHODS

We retrospectively reviewed the medical records and clinical photos of 214 adult AD patients (≥18 years of age) over a 3-year period. We classified the patients into 2 groups: early-onset (first onset of AD before 12 years of age) and late-onset (first onset of AD at 12 years of age or later).

RESULTS

Among 214 patients, 151 patients (70.6%) belonged to the early-onset group (mean age 24.5 years), while 63 patients belonged to the late-onset group (mean age 29.5 years). An association with allergic asthma or rhinitis, a family history of atopic disease, elevated total serum IgE, and sensitivity to food allergens were more commonly seen in the early-onset group. The late-onset group had a significant likelihood of nonflexural involvement (38.1% vs 13.2%). There was no significant difference in the mean eczema area severity index score, eosinophil count, and sensitivity to aeroallergens between 2 groups.

CONCLUSION

Adult AD shows different clinical and laboratory characteristics depending on the age of onset. This study could help to create awareness about the heterogeneity of AD in adulthood and encourage further studies on clinical outcomes and different therapeutic methods depending on the age of onset.

Journal of cutaneous medicine and surgery

Clinical and Laboratory Differences Between Early-Onset and Late-Onset Adult Atopic Dermatitis

J Cutan Med Surg 2020 Apr 22;[EPub Ahead of Print], DL Ha, GH Park, HS Kim, HC Ko, MB Kim, KM Lim, BS Kim 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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