Peso en la infancia incrementa HS
Association of Birth Weight, Childhood BMI, and Height With Risk of Hidradenitis Suppurativa
TAKE-HOME MESSAGE
The authors used a cohort of 347,200 Danish children and observed an increased risk of hidradenitis suppurativa (HS) developing in babies with both lightest (2.00–2.75 kg) and heaviest (4.26–5.50 kg) birth weights versus babies with normal birth weight. Children who developed overweight body mass index (BMI) between 7 and 13 years of age and children who were persistently overweight at 7 and 13 years were observed to have a significantly increased risk of HS (HR, 2.11 and 2.61, respectively). Interestingly, children who were overweight at age 7 but normal weight by age 13 did not have an increased risk of HS versus children who were never overweight.
- Increasing BMI in children is associated with a greater risk of developing HS. Monitoring body weight in childhood and reducing BMI to normal prior to puberty may reduce the risk of later developing hidradenitis suppurativa, which may be of particular interest in children with known genetic predisposition to this disease.
IMPORTANCE
There is a lack of evidence on the association of birth weight, childhood body mass index (BMI), change in BMI during childhood, and childhood height with subsequent risks of hidradenitis suppurativa (HS) in adulthood.
OBJECTIVE
To investigate the association of birth weight, childhood BMI, change in BMI during childhood, and childhood height with subsequent risks of HS in adulthood in a large Danish population-based cohort.
DESIGN, SETTING, AND PARTICIPANTS
This cohort study included 347 200 schoolchildren from the Copenhagen School Health Records Register born from 1930 to 1996 who were linked to the Danish National Patient Register of hospital discharge diagnoses to identify cases of HS. Birth weight was reported by parents or guardians, whereas childhood weight and height were measured by school physicians or nurses at ages 7 through 13 years. Cox proportional hazards regressions were used to estimate hazard ratios (HRs) and 95% CIs. Statistical analysis was performed from February 20, 2019, to May 15, 2019.
MAIN OUTCOMES AND MEASURES
A diagnosis of HS as recorded in the Danish National Patient Register.
RESULTS
Among the 347 200 children included in the study (175 750 boys) during the follow-up period from 1977 to 2017, 1037 individuals (677 females; median age at diagnosis, 39 years [range, 15-73 years]) received a diagnosis of HS. A nonlinear (U-shaped) association was found between birth weight and HS, such that both the lightest (2.00-2.75 kg; HR, 1.36 [95% CI, 1.10-1.68]) and the heaviest babies (4.26-5.50 kg; HR, 1.39 [95% CI, 1.01-1.93]) had increased risks of HS compared with normal-weight babies (3.26-3.75 kg; P = .04 for deviation from linearity). The risk of HS increased significantly with increasing BMI z score at each age from 7 to 13 years, from an HR of 1.32 (95% CI, 1.24-1.40) per BMI z score at 7 years of age to an HR of 1.50 (95% CI, 1.40-1.61) per BMI z score at 13 years of age. Compared with children with a normal weight at 7 and 13 years of age, those with a normal weight at 7 years of age and overweight at 13 years of age had a significantly increased risk of HS (HR, 2.11 [95% CI, 1.63-2.74]) and children with persistent overweight at both ages also had an increased risk of HS (HR, 2.61 [95% CI, 2.02-3.38]). Children with overweight at 7 years of age but with normal weight at 13 years of age did not have a significantly increased risk of HS (HR, 1.05 [95% CI, 0.67-1.67]). Childhood height at all ages was not associated with risk of HS (children at 7 years had an HR of 1.00 [95% CI, 0.94-1.07], and those 13 years had an HR of 1.06 [95% CI, 0.99-1.13], per z score).
CONCLUSIONS AND RELEVANCE
This cohort study found that both the lightest and heaviest babies had increased risks of HS. Childhood BMI was positively and significantly associated with risk of HS development in adulthood. These findings suggest that returning to normal weight before puberty reduces risks of HS to levels observed in children who were never overweight. Childhood height was not associated with risk of HS.
Association of Birth Weight, Childhood Body Mass Index, and Height With Risk of Hidradenitis Suppurativa
JAMA Dermatol 2020 Apr 29;[EPub Ahead of Print], AR Jørgensen, J Aarestrup, JL Baker, SF ThomsenSkin Care Physicians of Costa Rica
Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574
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posted by dermatica at
May 21, 2020
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