Comorbidities of Atopic Dermatitis in Adults
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In this cross-sectional study, adults with atopic dermatitis (AD) were compared with age- and sex-matched controls. AD patients had a higher risk of psychiatric disease, autoimmune disease, and infections compared with control subjects. Notably, AD patients were more likely to have several systemic diseases including lymphoid/hematopoietic malignancy, atherosclerosis, and metabolic syndrome.
- AD is associated with psychiatric and infectious disorders, as well as many systemic inflammatory conditions.
abstract
This abstract is available on the publisher's site.
BACKGROUND
Atopic dermatitis (AD) is a pruritic inflammatory skin disease associated with various comorbidities. However, comprehensive analyses of real-world comorbidities in adult AD patients are limited.
OBJECTIVE
To characterize the real-world comorbidities associated with adult AD in an ambulatory population.
METHODS
We queried the MarketScan Commercial Claims and Encounters database from January 1, 2017 to December 31, 2017. Multivariable logistic regressions were performed to compare comorbidities in adult AD patients vs. age- and sex-matched controls.
RESULTS
A total of 39,779 AD patients and 353,743 controls were identified. Increased odds of psychiatric conditions including anxiety (OR 1.44) and mood disorders (OR 1.31) were observed in AD. AD patients had higher likelihood of autoimmune diseases including vitiligo (OR 4.44) and alopecia areata (OR 6.01). Adult AD was also associated with infections including impetigo (OR 9.72), MRSA (OR 3.92), and cellulitis (OR 2.52). AD patients were more likely to have systemic conditions including lymphoid/hematopoietic malignancy (OR 1.91), atherosclerosis (OR 1.69), and metabolic syndrome (OR 1.47). For all the above, p<0.001.
LIMITATIONS
Retrospective analysis of healthcare claims data CONCLUSIONS: Adult AD is associated with various psychiatric and systemic comorbidities, emphasizing the systemic nature of AD and the need for collaborative management of these patients.
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Copyright © 2021 Elsevier Inc. All rights reserved.
Additional Info
Real-world comorbidities of atopic dermatitis in the U.S. adult ambulatory population
J Am Acad Dermatol 2021 Nov 17;[EPub Ahead of Print], YS Roh, AH Huang, N Sutaria, U Choi, S Wongvibulsin, J Choi, ZA Bordeaux, V Parthasarathy, J Deng, DP Patel, JK Canner, AL Grossberg, SG Kwatraposted by dermatica at
December 13, 2021
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