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Published in Dermatology and 

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Journal Scan / Research · June 08, 2020

Smell and Taste Disturbances Associated With Dermatological Medications and Relevance to COVID-19 Infections

TAKE-HOME MESSAGE

• The FDA Adverse Event Reporting Database was reviewed for dermatological medications associated with smell/taste disturbances. Medications reported in association with smell disturbances/anosmia/hyposmia included adalimumab, etanercept, terbinafine, cetirizine, vismodegib, secukinumab, prednisone, spironolactone, isotretinoin, and fluconazole, albeit present in low percentages (less than 1% of cases). Medications associated with taste disturbances included vismodegib, etanercept, terbinafine, apremilast, methotrexate, secukinumab, spironolactone, isotretinoin, tacrolimus, and mycophenolate (reported in 0.07–1.69% of cases).

• Given the common complaint of smell and taste disturbances in COVID-19 patients (about 1 out of 3) and limited COVID-19 testing availability, it is important to recognize that common dermatologic medications can cause these symptoms. Careful review of medications and appropriate counseling of patients presenting with smell/taste disturbances are warranted.

– InYoung Kim, MD, P

Abstract

Smell and taste disturbances are more recently reported symptoms of the novel Coronavirus disease 2019 (COVID-19) [1]. Many commonly used dermatological medications can also cause smell/taste changes. With COVID-19 testing shortages in the United States (US), these medication adverse events warrant careful consideration. In this study, we analyzed the US Food and Drug Administration (FDA) Adverse Event Reporting Database (FAERS) for the most common dermatological medications associated with smell/taste disturbances, and their relevance to COVID-19 infections.

Journal of the American Academy of Dermatology

Retrospective Analysis of Smell and Taste Disturbances Associated With Dermatological Medications Reported to the United States Food and Drug Administration and Relevance to COVID-19 Infections

J Am Acad Dermatol 2020 May 17;[EPub Ahead of Print], Y Wang, SR Lipner

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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