Minoxidil Oral en AA

Very Low–Dose Oral Minoxidil in Male Androgenetic Alopecia

Journal of the American Academy of Dermatology

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• Thirty-two men (18–45 years of age) with androgenetic alopecia (Hamilton–Norwood scale III–V) were treated with oral minoxidil 1.25 mg daily monotherapy. At 24 weeks, global clinical photographic assessment showed marked improvement in 43.8% and mild improvement in 40.6%. Quantitative digital videotrichoscopic assessment demonstrated a significant increase in hair shaft diameter from baseline in 78.1% of patients, with maximum improvement at the vertex (50 µm to 68.1 µm, P < .01). There was a 48.4% increase in hair density at the vertex. One patient discontinued treatment due to peripheral edema and hypertrichosis of lip and arms.

• This small 6-month study suggests that low-dose minoxidil at 1.25 mg daily can be an effective treatment option for male androgenetic alopecia with low rates of adverse events. Higher doses (2.5–5 mg/day) may be considered for those without response.

– InYoung Kim, MD, PhD

Abstract

Oral minoxidil (OM) has been used with significant improvement in androgenetic alopecia (AGA) in patients of either gender.1-4 In men with AGA, OM has been used alone, and in combination with other therapies and in doses varying from 0.25 mg/day to 2.5-5 mg/day.2,3 Some of the reported adverse effects of such lower doses of OM include lower limb edema, generalized hypertrichosis, hair shedding, urticaria, and other allergic reactions.1-4 In this case series, we share our experience of using 1.25 mg/day of OM monotherapy in 32 patients with male AGA.

Journal of the American Academy of Dermatology

Efficacy and Safety of Very Low Dose Oral Minoxidil 1.25 mg in Male Androgenetic Alopecia

J Am Acad Dermatol 2020 May 31;[EPub Ahead of Print], A Jha, S Sonthalia, Zeeshan, K Vinay 

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Benjamin Hidalgo-Matlock
Skin Care Physicians of Costa Rica

Clinica Victoria en San Pedro: 4000-1054
Momentum Escazu: 2101-9574

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